CJC No Dac Overview

CJC-1295 No DAC is a synthetic 29-amino acid peptide analog of Growth Hormone-Releasing Hormone (GHRH). It is a modified version of the shortest fully functional fragment of GHRH, known as Sermorelin (GRF 1-29). By replacing four specific amino acids in the sequence, researchers created a molecule with a significantly higher affinity for GHRH receptors and greater resistance to enzymatic breakdown.

Core Functions:

• Pulsatile GH Release: Unlike the “DAC” version, No DAC allows for natural, episodic “pulses” of growth hormone, preserving the body’s natural hormonal rhythm.
• Metabolic Optimization: Studied for its role in enhancing lipolysis (fat burning) and improving cellular energy expenditure.
• Protein Synthesis: Research focuses on its ability to increase nitrogen retention, which is a key marker for muscle tissue preservation and repair.
• Pituitary Support: Directly stimulates the somatotrophs in the anterior pituitary to produce and secrete endogenous GH.

History

The development of CJC-1295 No DAC stems from the early work on Sermorelin in the 1980s. While Sermorelin was effective, it was degraded by the body within minutes. In the mid-2000s, researchers developed the “tetra-substitution” method to make the peptide more durable. The “No DAC” distinction became crucial when ConjuChem added a Drug Affinity Complex (DAC) to the molecule to extend its life to several days. Researchers who preferred a natural, pulsatile GH release shifted their focus back to the version without the complex, cementing its place as the preferred GHRH analog for rhythmic hormonal research.

CJC No Dac Structure:

Chemical Name: Mod GRF 1-29 (Tetrasubstituted)
Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂
CAS Number: 448753-11-9
Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight: ~3367.9 g/mol
PubChem CID: 56841936

Key Research Findings

CJC No Dac has been studied in multiple non-human laboratory settings, including cell culture and animal models. Reported areas of scientific investigation include:

• Pulsatile GH Secretion: Research confirms that No DAC maintains the natural “ebb and flow” of GH, which is considered safer for long-term pituitary health.
• IGF-1 Elevation: Demonstrates a steady increase in systemic IGF-1, which promotes the repair of bone, muscle, and skin tissues.
• Visceral Fat Oxidation: Studies show a marked increase in the breakdown of adipose tissue, particularly in the abdominal region.
• Enhanced Slow-Wave Sleep: Associated with improved deep sleep cycles, where the majority of physical recovery occurs.
• Muscle Cell Hyperplasia: Investigated for its potential to stimulate the growth of new muscle cells rather than just the enlargement of existing ones.
• Anti-Aging Markers: Research suggests improved skin elasticity and collagen density in aging animal models.
• Synergy with GHRPs: Findings consistently show that when used with a GHRP (like Ipamorelin), the GH release is exponentially greater than when used alone.
• Stability: The tetra-substitution (replacing four amino acids) makes it significantly more resistant to the DPP-IV enzyme compared to Sermorelin.

Scientific Summary

CJC-1295 No DAC (Mod GRF 1-29) is a tetrasubstituted peptide analog designed to stimulate the secretion of Growth Hormone. In laboratory models, it is used to study the hypothalamic-pituitary-somatotropic axis. By modifying the 2nd, 8th, 15th, and 27th positions of the original GRF 1-29 sequence, this peptide exhibits a half-life of approximately 30 minutes—long enough to trigger a robust GH pulse, but short enough to avoid “GH bleed” or the desensitization of pituitary receptors.

Important Research Notice

Current published research on CJC-1295 No DAC is based on laboratory and preclinical studies. It has not been approved by the FDA for the treatment of any medical condition. Existing research does not establish definitive safety or efficacy for human use. This molecule is intended strictly for laboratory research purposes.

References

1. CJC-1295: A Long-Acting GHRH Analog for Research
2. Comparison of GHRH Analogs and Pituitary Response
3. Mod GRF 1-29 and the Stimulation of Pulsatile GH

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