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CJC/Ipa

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Peptides will arrive in a lyophilized (powder) form for maximum stability

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CJC/Ipa Overview

CJC/Ipa is a synergistic combination of two distinct Growth Hormone Secretagogues (GHS). CJC-1295 is a long-acting analog of Growth Hormone Releasing Hormone (GHRH), while Ipamorelin is a selective Growth Hormone Releasing Peptide (GHRP). Together, they mimic the natural pulsatile release of GH by stimulating the pituitary gland from two different pathways.

Core Functions:

  • Synergistic GH Release: CJC-1295 acts as a “gas pedal” by signaling the pituitary to produce GH, while Ipamorelin inhibits somatostatin (the “brake”), allowing for a more potent release.

  • Metabolic Enhancement: Research focuses on their ability to increase basal metabolic rate and promote the oxidation of adipose tissue (fat loss).

  • Lean Muscle Preservation: Studied for their role in nitrogen retention and protein synthesis, which are essential for maintaining lean muscle mass.

  • Improved Sleep Quality: Both peptides are associated with an increase in deep (slow-wave) sleep, which is the primary window for physiological repair.


History

CJC-1295 was originally developed by ConjuChem Technologies in the mid-2000s to treat fat loss in specific clinical populations. Around the same time, Ipamorelin was developed by Novo Nordisk as a more refined alternative to older GHRPs (like GHRP-2 or GHRP-6), which often had unwanted side effects. Researchers eventually began combining the two to achieve a “synergistic pulse” that more closely resembles the body’s natural hormonal rhythms, leading to its current status as a cornerstone in regenerative and metabolic research.


CJC/Ipa Structure

Chemical Name: CJC-1295 (No DAC)
Sequence: Tyr-d-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂
CAS Number: 448753-11-9
Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight: ~3367.9 g/mol
PubChem CID: 56841936

 

Chemical Name: Ipamorelin
Sequence: Aib-His-d-2-Nal-d-Phe-Lys-NH₂
CAS Number: 170851-70-4
Molecular Formula: C₃₈H₄₉N₉O₅
Molecular Weight: ~711.85 g/mol
PubChem CID: 9831659


Key Research Findings

CJC/Ipa has been studied in multiple non-human laboratory settings, including cell culture and animal models. Reported areas of scientific investigation include:

1. Optimized Body Composition

Studies consistently show a reduction in visceral fat and an increase in lean muscle mass in animal models.

2. Enhanced Recovery

Research indicates accelerated repair of soft tissues and skin after injury or surgery.

3. Bone Mineral Density

Preliminary findings suggest that elevated GH levels support the strengthening of the skeletal matrix.

4. Selectivity

Ipamorelin has been shown to have a high safety profile in trials, specifically avoiding the stimulation of hunger or cortisol spikes.

5. Cardiovascular Support

Emerging research looks at the role of GHS peptides in improving heart rate variability and cardiac output.

6. Cognitive Function

Investigated for its potential to support neurogenesis and protect against age-related cognitive decline.

7. Immune Support

Elevated GH levels are linked to the rejuvenation of the thymus gland, enhancing T-cell production.

8. Lipolysis Acceleration

CJC-1295 specifically aids in the breakdown of stubborn fat stores by increasing IGF-1 levels systemically.


Scientific Summary

The CJC-1295 and Ipamorelin combination represents a sophisticated approach to studying the Growth Hormone (GH) axis. CJC-1295 (typically studied in its “No DAC” form for pulsatile effect) is a synthetic 29-amino acid peptide that increases plasma GH levels. Ipamorelin, a pentapeptide, is considered the most selective GHRP because it stimulates GH without significantly affecting cortisol, prolactin, or appetite-stimulating hormones like ghrelin. In preclinical research, this blend is used to study the long-term effects of optimized GH levels on body composition, bone density, and cellular repair.


Important Research Notice

Current published research on CJC-1295 and Ipamorelin is largely based on laboratory and preclinical studies. This combination has not been approved by the FDA for the treatment, prevention, or cure of any disease. Research does not establish definitive safety or clinical outcomes for therapeutic use in humans. These molecules are restricted to laboratory research purposes only.


References

  1. Ipamorelin: A Selective Growth Hormone Secretagogue
  2. CJC-1295: A Long-Acting GHRH Analog
  3. The Synergistic Effects of GHRH and GHRP on Growth Hormone Secretion

 

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Peptides are short chains of amino acids that occur naturally in organisms, where they act as messengers in many biological systems. While some peptides have been developed for medical use, laboratory research focuses on understanding their activity at the cellular level, examining how they impact essential processes in vitro.

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Peptides are supplied as lyophilized powder. They do not come reconstituted, and any extra supplies must be sourced separately for research applications.

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