Ipamorelin research overview — sequence, class, and analytical context
A documented overview of Ipamorelin (Pentapeptide-22) for research use — its sequence and class as a growth-hormone secretagogue, the receptor pathway it acts on in research models, stability considerations, and the analytical specifications a credible lot should meet.
Ipamorelin, also designated Pentapeptide-22, is a synthetic pentapeptide studied as a growth-hormone secretagogue. This overview covers what the analytical and research record establishes — the peptide's sequence, its receptor class in research models, how it is handled, and the specifications a research-grade lot should meet. It makes no therapeutic claims; Ipamorelin here is a reference compound for laboratory research, not for human consumption.
The short version: Ipamorelin is studied as a selective growth-hormone secretagogue — a ghrelin-receptor agonist notable in the research literature for a comparatively clean secretory profile.
Sequence and physical properties
Ipamorelin is a five-residue peptide with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂ and a molecular weight of approximately 711.9 g/mol. The presence of non-natural residues (Aib and D-amino acids) contributes to its stability relative to purely natural-sequence peptides. As a research material it presents as a white lyophilized powder and is soluble in water and bacteriostatic water.
Class and research context
Ipamorelin acts in research models as an agonist at the growth-hormone secretagogue receptor (GHS-R), the same receptor targeted by the endogenous ligand ghrelin. What distinguishes it in the published research literature is selectivity: studies have characterized it as stimulating growth-hormone release with comparatively little effect on cortisol, prolactin, and ACTH relative to some earlier secretagogues. That selectivity is why it appears frequently as a reference compound in growth-hormone-axis research.
Analytical specifications a credible lot should meet
A research-grade Ipamorelin lot should be characterized by identity (mass spectrometry against the theoretical mass), purity (HPLC with the detection wavelength stated), and an endotoxin screen. Lumin's Ipamorelin reference material is released at 99.82% HPLC purity for lot 24-2484, with the full analytical record published in the COA library. For how to interpret those numbers on any vendor's document, see how to vet a research-peptide supplier.
Handling and stability
Lyophilized Ipamorelin is stable stored cold and dry. The non-natural residues improve resistance to enzymatic degradation, but reconstituted peptide is still best kept cold and used within a limited window; peptide stability under storage is well documented in the analytical literature. These are handling notes for laboratory research only.
Related compounds in the same research area
Ipamorelin is commonly studied alongside other growth-hormone-axis compounds. The closest catalog relative is Tesamorelin, a GHRH analog that acts on a different point of the same axis — the two are frequently characterized together in growth-hormone-secretagogue research panels.
Common questions
What is Pentapeptide-22? It is the systematic cosmetic/research designation for Ipamorelin — the same five-residue peptide.
Why is "selectivity" the headline in the research literature? Because research has characterized Ipamorelin as releasing growth hormone with comparatively little disturbance of other hormones, which makes it a cleaner tool compound in mechanistic studies.
What lot documentation should ship with it? Identity by mass spec, HPLC purity with wavelength, and an endotoxin result — all tied to the specific lot in hand.
Lumin Research supplies Ipamorelin and related compounds for laboratory and research use only. Not for human consumption. Not a drug, dietary supplement, or diagnostic or therapeutic product. US lab · third-party HPLC purity · endotoxin tested per batch · third-party COA published per lot.